BOTOX DERMAL FILLERS AND WRINKLE REMOVERS AND A REVIEW OF WRINKLE AND SKIN AGING TREATMENTS THAT WORK ON COLLAGEN
What works with wrinkles and skin aging? At least 3 different wrinkle removers and skin aging treatments are reviewed in a dermatology journal article. Actually as I have written in healty medical Blog previously there are a variety of ways to deal effectively with wrinkles. These include Botox injections, radiowave therapy for wrinkles as well as dermal fillers. These methods definitely work. The run away popularity of Botox speaks for itself. But a recent review in the Archives of Dermatology with the catchy title "Looking Older Fibroblast Collapse and Therapeutic Implications" focuses on 3 skin aging and wrinkle treatments. Each wrinkle and skin aging treatment depends on the same mechanism, the interaction of skin cells called fibroblasts with the collagen they produce.
"Clinically proven antiaging treatments such as topical retinoic acid, carbon dioxide laser resurfacing, and intradermal injection of cross-linked hyaluronic acid stimulate production of new, undamaged collagen. Attachment of fibroblasts to this new collagen allows stretch, which in turn balances collagen production and degradation and thereby slows the aging process. Collagen fragmentation is responsible for loss of structural integrity and impairment of fibroblast function in aged human skin. Treatments that stimulate production of new, nonfragmented collagen should provide substantial improvement to the appearance and health of aged skin".
As the NY Times writes, "The key is a growing understanding of the skin’s connective tissue, called the dermal collagen, and a recognition that damage to the mechanical properties of the collagen outside the skin cells, and not necessarily genetic damage to the cells themselves, causes wrinkled skin".
"A recent review in The Archives of Dermatology concludes that three anti-aging treatments are proven clinically effective: the topical application of retinol; carbon dioxide laser resurfacing; and injection of hyaluronic acid, a moisture-retaining acid that occurs naturally in the skin. Each depends on the same mechanism, the interaction of skin cells called fibroblasts with the collagen they produce".
"Among the clinical features of photoaging, wrinkles have been a focus of extensive studies over the past decade. Compared with sun-protected skin, such as the buttock, photoaged skin has less procollagen formation. Well-established treatments for photoaging, such as carbon dioxide laser resurfacing or topical retinoic acid, stimulate procollagen synthesis and increase the mature collagen band in the high dermis (papillary dermis). This increase in dermal collagen is associated with wrinkle effacement. Because accelerated skin aging due to excessive sun exposure has marked collagen deficiency and effective treatments for photoaging promote procollagen synthesis, we hypothesized that similar therapies might also improve the collagen deficiency found in intrinsic aging. For intrinsically aged skin, however, use of ablative lasers such as carbon dioxide is not feasible because it induces significant wounding that takes several weeks to heal".
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