VIDEOS WHAT ARE THE BENEFITS OF VITAMIN D ANOTHER REPORT ASKS IS LOW VITAMIN D BAD FOR THE HEALTH LOWER VITAMIN D AND HEART PROBLEMS

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Here are video reports that discuss the recent interest in what are the benefits of Vitamin D? Or at least what are some of the new research findings about what Vitamin D might do or not. How do I love thee Vitamin D? Let me count the ways. Still another medical report has appeared about the putative relationship between Vitamin D and health.



Earlier the Archives of Internal Medicine had a report about a relationship between low Vitamin D and heart attacks. Now another report says "Low 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels (which are ways of measuring Vitamin D in the body) are independently associated with all-cause and cardiovascular (heart) mortality. (But) A causal relationship has yet to be proved by intervention trials using vitamin D".




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Now it is Vitamin D and the risk of heart attack and heart problems .It seems like Vitamin D has arrived in the medical spot light. Recently I wrote in healty medical Blog that the Canadian Cancer Society has recommended that many people take Vitamin D and I also scoped out a report that said that women with breast cancer who had low levels of Vitamin D did less well prognosis wise. Now fanning the flames of Vitamin D popularity is a study that says "Low levels of 25(OH)D (Vitamin D) are associated with higher risk of myocardial infarction (heart attack) in a graded manner, even after controlling for factors known to be associated with coronary artery disease" (heart problems related to the coronary arteries that supply the heart muscle itself with blood).



Watch this video about a possible relationship between Vitamin D and cancer Click the arrow to start







The report about Vitamin D and heart and all cause mortality was published in the June 23 edition of the Archives of Internal Medicine.In the study, Dr. Harald Dobnig, from the Medical University of Graz in Austria, and colleagues collected data on vitamin D levels among almost 3,300 patients undergoing angiography. Angiography is the medical procedure where dye is injected to "light up" the heart coronary arteries when viewed with xray to check for coronary blockage.



"After more than seven years of follow-up, 737 patients had died, 463 of them from cardiovascular disease. Dobnig's team found that death rates from any cause, and from cardiovascular disease, were higher among people with the lowest levels of vitamin D". "Although not proved, it seems possible that at least part of this effect may be due to lowering of a risk profile promoting atherosclerosis and preventing cardiovascular end points," they concluded".

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"Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles, noted that similar observations with low vitamin E and beta carotene levels and cardiovascular mortality were not confirmed when vitamin supplementation was tested in clinical trials. "Prospective randomized clinical trials of vitamin D supplementation demonstrating a reduction in cardiovascular mortality are absolutely needed before any treatment recommendations can be made," Fonarow said. "The few clinical trials of vitamin D supplementation conducted to date have been quite disappointing."



"Vitamin D also appears to play a role in preventing heart failure, another study finds.In a study, published online in Journal of Cardiovascular Pharmacology, University of Michigan pharmacologist Simpson showed that vitamin D could prevent heart failure from developing in rats".

Click healty medical Canadian Cancer Society Recommends Many Take Vitamin D

Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality

What About Vitamin D and Pancreatic Cancer



In the report about Vitamin D and the heart they say "Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans".The scientists examined the blood levels of Vitamin D in thousands of men between the ages of 40 and 75. "We assessed prospectively whether (blood) plasma 25-hydroxyvitamin D (25[OH]D) ,(Vitamin D) concentrations are associated with risk of coronary heart disease".



Very few foods in nature contain vitamin D. The flesh of fish (such as salmon, tuna, and mackerel) and fish liver oils are among the best sources. Blood serum concentration of 25(OH)D is the best indicator of Vitamin D status. It reflects vitamin D produced in the skin and that obtained from food and supplements and has a fairly long circulating half-life of 15 days. "A nested case-control study was conducted in 18 225 men in the Health Professionals Follow-up Study; the men were aged 40 to 75 years and were free of diagnosed cardiovascular disease at blood collection. Low levels of 25(OH)D are associated with higher risk of myocardial infarction (heart attack)in a graded manner, even after controlling for factors (that is making adjustments to the calculations for other things that could cause coronary heart problems) known to be associated with coronary artery disease".

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25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men

VITAMIN D AND PANCREATIC CANCER DOES VITAMIN D HELP PREVENT PANCREATIC CANCER AND A REPORT FROM HARVARD AND NORTHWESTERN

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With the stories of Pavarotti and Swayze, pancreatic cancer has been in the news. Recently I wrote about treatment at Johns Hopkins for pancreatic cancer. With the opera star Marilyn Horne getting surgery as well as a vaccine for pancreatic cancer. In an unrelated story researchers have been investigating the possible benefits of vitamin D in preventing medical problems, possibly even some forms of cancer. In fact the Canadian Cancer Society has recommended vitamin D. But it turns out that researchers at Harvard and Northwestern have looked at a possible role of vitamin D in prevention of pancreatic cancer.

Vitamin D vs pancreatic cancer and what is a cohort study

In 2006 Harvard and Northwestern scientists illuminated a possible benefit of vitamin D against pancreatic cancer in the journal Cancer Epidemiology Biomarkers and Prevention. The researchers wrote "We observed that a higher intake of vitamin D was associated with a decreased risk for pancreatic cancer in two large U.S. cohorts. (A cohort is a group of people who share a common characteristic or experience within a defined period (e.g., are born, leave school, lose their job, are exposed to a drug or a vaccine, etc.)...In this analysis of two large prospective cohort studies, we observed a reduced risk for pancreatic cancer with higher intake of vitamin D. Participants consuming 600 IU/d or more of vitamin D experienced a 41% lower risk for pancreatic cancer when compared with those consuming less than 150 IU/d".

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We cannot exclude the possibility that vitamin D may be acting as a surrogate for some other, as yet unknown, factor that is associated with the risk for pancreatic cancer. However, in our multivariable analyses, we controlled for factors previously associated with pancreatic cancer(such as cigarette smoking), as well as other potential confounders, including multivitamin supplement use and calcium and retinol intake. Adjusting for multivitamin supplement use strengthened the association between total vitamin D intake and the risk for pancreatic cancer, particularly at the highest levels of intake. We have previously reported a modest positive association between multivitamin supplement use and the risk of pancreatic cancer and this raised the possibility that some factor in multivitamin supplements other than vitamin D, potentially retinol, antagonizes a protective effect of vitamin D, or plays an independent role in increasing the risk for pancreatic cancer. Moreover, when excluding multivitamin supplement users, we continued to observe an inverse relation between vitamin D from food sources and the risk for pancreatic cancer".




"Two ongoing cohort studies provided data for our analyses: the Nurses' Health Study (NHS), and the Health Professionals Follow-up Study (HPFS). The NHS was initiated in 1976 when 121,701 U.S. female registered nurses ages 30 to 55 years responded to a mailed questionnaire. The HPFS began in 1986 when 51,529 U.S. male health professionals ages 40 to 75 years responded to a mailed questionnaire".




"To our knowledge, this is the first epidemiologic report of an association between vitamin D intake and the risk for pancreatic cancer...In concert with laboratory demonstrations of antitumor effects of vitamin D, our results point to a potential role for the vitamin D pathway in the prevention and pathogenesis of pancreatic cancer. Considering the paucity of epidemiologic data on this malignancy, additional study of vitamin D and pancreatic cancer is warranted".

Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies