Does It Matter What Time You Take Blood Pressure Medication? For People with Poorly Controlled Blood Pressure One Study Says Try Closer to Bedtime
Does Your Body Clock Circadian Rhythm Influence How Your Blood Pressure Medicine Works?
Did This Study in Spain Say That Some People Had better Control of Blood Pressure When They Took Their Medication Toward Bedtime?
MAPEC STUDY: Bedtime chronotherapy with ≥1 BP-lowering medications, compared to conventional upon-waking treatment with all medications, more effectively improved BP control, better decreased the prevalence of non-dipping, and, most importantly, significantly reduced cardiovascular morbidity and mortality.
It may help some people with high blood pressure to take some blood pressure medication toward the evening. The MAPEC Study in Spain studied people with hard to control blood pressure or who weren't being treated at all."Clinical studies have documented morning-evening, administration-time differences of several different classes of hypertension (high blood pressure) medications in blood pressure (BP)-lowering efficacy, duration of action, safety profile, and/or effects on the circadian (the body's natural biological clock) blood pressure pattern. In spite of these published findings, most hypertensive subjects, including those under combination therapy, are instructed by their physicians and pharmacists to ingest all of their BP-lowering medications in the morning. The potential differential reduction of cardiovascular (CVD) ..injury or worse .. risk by a bedtime versus upon-awakening treatment schedule has never been evaluated prospectively. The prospective MAPEC study was specifically designed to test the hypothesis that bedtime chronotherapy with ≥1 hypertension medications exerts better BP control and CVD risk reduction than conventional therapy."
The people were assigned to one of 2 groups. One group took all their blood pressure medication in the AM and the other took one or more of the medications at bedtime. It is common for people to need more than one type of blood pressure medicine.
What Happened to the Blood pressure of the People in the 2 Groups?
Throughout the study people in the bedtime dosing group had lower average asleep blood pressures. They also had better average blood pressure during the day. The bedtime dosing group was also found to have fewer cardiovascular events.
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